کلشی سین سیگما

C9754

Colchicine

لینک کالا در سایت سیکما ( کلیک کنید )

برگه انالیز کالا ( کلیک کنید )

دیتا شیت ( کلیک کنید )

sds ( کلیک کنید )

C9754

Colchicine

≥95% (HPLC), powder

Synonym(s):
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

Empirical Formula (Hill Notation):
C22H25NO6

CAS Number:
64-86-8
Molecular Weight:
399.44
Beilstein:
2228813
EC Number:
200-598-5
MDL number:
MFCD00078484
PubChem Substance ID:
24278348
NACRES:
NA.77

General description

Colchicine is a secondary metabolite,[1] which has anti-inflammatory properties.[2] It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines.[2] It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.[1]

Application

Colchicine has been used:

• in the in vitro sister-chromatid exchange (SCE) assay[3]
• to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities[4]
• in microtubule disruption[5]
• to analyse its effects on Ca2+ transients from taxol-treated cells[6]

Packaging

100, 500 mg in poly bottle1, 5 g in poly bottle

Biochem/physiol Actions

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.