پیریلامین مالئات سالت Pyrilamine maleate salt P5514-5G SIGMA

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Pyrilamine maleate salt

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5 G

€48.58

25 G

€131.00

100 G

€268.00

Synonym(s):

Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt

Empirical Formula (Hill Notation):

C17H23N3O · C4H4O4

CAS Number:

59-33-6

Molecular Weight:

401.46

EC Number:

200-422-7

MDL number:

MFCD00069333

UNSPSC Code:

12352116

PubChem Substance ID:

24277797

NACRES:

NA.77

Properties

form

powder

Quality Level

100

originator

Watson

SMILES string

OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

InChI

1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

JXYWFNAQESKDNC-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

Description

Application

Pyrilamine maleate salt has been used:

• to treat Cassiopea sp. as H1 receptor antagonist[1]

• to intraperitoneally inject mice to prevent the release of endogenous histamine[2]

• in membrane binding assay to determine the Ki values and in the comparative inhibitory concentration (IC50) studies by whole-cell patch clamp technique[3]

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.[1]

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.