پروتئین پایه میلین Myelin Basic Protein bovine M1891 SIGMA
پروتئین پایه میلین Myelin Basic Protein bovine
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Myelin Basic Protein bovine
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≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay
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Change View1 MG£45.105 MG£191.0025 MG£654.00Synonym(s):MBPMDL number:MFCD00131640NACRES:NA.32
M1891-1MG
£45.10
Availability
Available to ship on02 April 2024Details
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PROPERTIES
biological source
bovine
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
18.4 kDa
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1 mg/mL, clear, colorless to faintly yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... MBP(618684)
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View Price and Availabilityassay
≥90% (SDS-PAGE)
assay
≥80% (SDS-PAGE)
assay
≥95% (SDS-PAGE)
assay
≥98% (SDS-PAGE)
form
lyophilized powder
form
lyophilized powder
form
lyophilized powder
form
lyophilized powder
mol wt
18.4 kDa
mol wt
-
mol wt
-
mol wt
16.79 kDa
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
storage condition
-
storage condition
-
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
technique(s)
-
technique(s)
ELISA: suitable
technique(s)
ligand binding assay: suitable
DESCRIPTION
General description
Research Area: Cell Signaling
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids[1] with a methyl-arginine, is a peripheral membrane protein.[2] This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.[3]
Application
Myelin Basic Protein (MBP) bovine has been used:
- in in vitro methylation reaction[4][5]
- as a substrate in in vitro immunoprecipitation-kinase assay to measure Cds1 (the S-phase-specific checkpoint effector kinase) activity[6]
- to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays[7]
Used as a kinase substrate.
Biochem/physiol Actions
Mutation of the myelin basic protein gene induces dysmyelination. It is used to induce experimental allergic encephalomyelitis.Myelin basic protein (MBP) plays a vital role in the formation of the myelin sheath and is associated with various neurological disorders. MBP functions as an antigenic target in the autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositide, and regulation of calcium homoeostasis.[8] MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzymes.[9]MBP serves as a potential neuroreceptor. It can stimulate the proliferation of lymphocytes in vitro. MBP plays a key role as a substrate in the mitogen-activated protein (MAP) kinase activation pathway.[10] Based on lymphocyte stimulation, MBP can be used to detect cancer. It is used in several immunological studies. MBP also contributes to the preservation of the lipid: protein organization within myelin.[2]
Quality
May contain traces of urea-glycine buffer salts.