دگزامتازون Dexamethasone D1756 SIGMA

Name: دگزامتازون Dexamethasone D1756 SIGMA
SKU: IN1714970902
Availability: InStock

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دگزامتازون Dexamethasone D1756 SIGMA

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D1756

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Dexamethasone

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≥98% (HPLC), powder

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Change View25 MG€37.30100 MG€87.30500 MG€267.001 G€407.005 G€1,660.00Synonym(s):(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone FEmpirical Formula (Hill Notation):C22H29FO5CAS Number:50-02-2Molecular Weight:392.46Beilstein:2066651EC Number:200-003-9MDL number:MFCD00064136PubChem Substance ID:24893536NACRES:NA.77

PROPERTIES

Quality Level

200

Assay

≥98% (HPLC)

form

powder

color

off-white

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

DESCRIPTION

Application

Dexamethasone has been used:

in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue[1]
as a component of adipocyte differentiation medium[2]
for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)[3]

Biochem/physiol Actions

Dexamethasone is known to be effective against relapsed multiple myeloma.[4] It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.[5]Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.This compound was developed by Merck &amp; Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.