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دگزامتازون Dexamethasone D1756-25MG SIGMA

دگزامتازون Dexamethasone D1756-25MG SIGMA

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دگزامتازون Dexamethasone D1756-25MG SIGMA

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برگه انالیز کالا ( کلیک کنید )

D1756

Sigma-Aldrich

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Dexamethasone

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≥98% (HPLC), powder

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25 MG

€37.30

100 MG

€87.30

500 MG

€267.00

1 G

€407.00

5 G

€1,660.00

Synonym(s):

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

Empirical Formula (Hill Notation):

C22H29FO5

CAS Number:

50-02-2

Molecular Weight:

392.46

Beilstein:

2066651

EC Number:

200-003-9

MDL number:

MFCD00064136

UNSPSC Code:

51422306

PubChem Substance ID:

24893536

NACRES:

NA.77

Properties

Quality Level

200

Assay

≥98% (HPLC)

form

powder

color

off-white

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ...
Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ...
Ar(24208) , Nr3c1(24413) , Tnf(24835)

Description

General description

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways,[1] some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

Application

Dexamethasone has been used:

  • in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue[2]

  • as a component of adipocyte differentiation medium[3]

  • for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)[4]

Biochem/physiol Actions

Dexamethasone is known to be effective against relapsed multiple myeloma.[5] It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.[6]

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

Reconstitution

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.