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D1756
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25 MG
€37.30
100 MG
€87.30
500 MG
€267.00
1 G
€407.00
5 G
€1,660.00
Synonym(s):
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
Molecular Weight:
392.46
Beilstein:
2066651
EC Number:
MDL number:
UNSPSC Code:
51422306
PubChem Substance ID:
NACRES:
NA.77
≥98% (HPLC)
powder
off-white
262-264 °C (lit.)
methanol: 25 mg/mL
Merck & Co., Inc., Kenilworth, NJ, U.S.
2-8°C
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
UREBDLICKHMUKA-CXSFZGCWSA-N
human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)
Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways,[1] some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.
Dexamethasone has been used:
in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue[2]
as a component of adipocyte differentiation medium[3]
for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)[4]
Dexamethasone is known to be effective against relapsed multiple myeloma.[5] It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.[6]
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Bottomless glass bottle. Contents are inside inserted fused cone.
Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.
Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.