اکتینومایسین D سیگما Actinomycin D A9415-5MG
اکتینومایسین D سیگما Actinomycin D A9415-5MG
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A9415
Actinomycin D
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from Streptomyces sp., suitable for cell culture, ≥95%
Synonym(s):Cosmegen, Meractinomycin, Actinomycin C1, Actinomycin IV, DactinomycinEmpirical Formula (Hill Notation):C62H86N12O16CAS Number:50-76-0Molecular Weight:1255.42Beilstein:605235EC Number:200-063-6MDL number:MFCD00005033PubChem Substance ID:24891447NACRES:NA.76Sign Into View Organizational & Contract PricingSKUPack SizeAvailabilityPriceA9415-2MG2 mgAvailable to ship on December 11, 2023Details...€233.00A9415-5MG5 mgAvailable to ship on December 11, 2023Details...€361.00A9415-10MG10 mgAvailable to ship on December 11, 2023Details...€917.00A9415-25MG25 mgOnly 3 left in stock (more on the way)Details...€1,640.00
PROPERTIES
biological source
Streptomyces sp.
Quality Level
Assay
≥95%
form
powder
technique(s)
cell culture | mammalian: suitable
color
red, powder
mp
251-253
solubility
ethanol, DMSO: soluble (Stable in aqueous solutions at 2-8 °C.)
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
DESCRIPTION
General description
Chemical structure: peptide
Application
Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas. Recommended for us in cell culture applications at 1μg/mL.
Biochem/physiol Actions
Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
Caution
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.
Preparation Note
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P201 - P202 - P264 - P270 - P280 - P301 + P310
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
Storage Class Code
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves