ان-اتیل مالی ایمید SIGMA N-Ethylmaleimide crystalline, ≥98% (HPLC) E3876-25G

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E3876

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N-Ethylmaleimide

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crystalline, ≥98% (HPLC)

Synonym(s):

NEM

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5 G

€119.00

25 G

€454.00

100 G

€1,210.00

About This Item

Empirical Formula (Hill Notation):

C6H7NO2

CAS Number:

128-53-0

Molecular Weight:

125.13

Beilstein:

112448

EC Number:

204-892-4

MDL number:

MFCD00005509

UNSPSC Code:

12352106

PubChem Substance ID:

24278420

NACRES:

NA.21

Properties

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (HPLC)

form

crystalline

storage condition

(Tightly closed. Dry. Keep in a well-ventilated place. )

technique(s)

activity assay: suitable
co-immunoprecipitation (co-IP): suitable
immunoblotting: suitable

color

white to faint yellow

bp

210 °C (lit.)

mp

43-46 °C (lit.)

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan

suitability

suitable for Western blot

application(s)

life science and biopharma

storage temp.

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

Gene Information

human ... KCNQ2(3785) , KCNQ4(9132) , KCNQ5(56479) , SLC6A3(6531) , SLC6A4(6532)

Description

Application

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Preparation Note

NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.

Other Notes

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