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کالای فیزیکی

آمفوتریسین بی Amphotericin B from Streptomyces sp. A4888-100MG

Name: آمفوتریسین بی Amphotericin B from Streptomyces sp. A4888-100MG
SKU: IN1722158081
Availability: InStock

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آمفوتریسین بی Amphotericin B from Streptomyces sp. A4888-100MG

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آمفوتریسین بی Amphotericin B from Streptomyces sp. A4888-100MG

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برگه انالیز کالا ( کلیک کنید )

A4888

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**Amphotericin B from Streptomyces sp.**

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~80% (HPLC), powder

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100 MG

$70.20

250 MG

$153.00

500 MG

$272.00

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$514.00

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$1,351.00

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Synonym(s):

LNS-AmB, NSC 527017, Fungizone

Empirical Formula (Hill Notation):

C47H73NO17

CAS Number:

1397-89-3

Molecular Weight:

924.08

Beilstein/REAXYS Number:

78342

EC Number:

215-742-2

MDL number:

MFCD00877763

PubChem Substance ID:

57653841

NACRES:

NA.85

Properties

biological source

Streptomyces sp.

Quality Level

300

assay

~80% (HPLC)

form

powder

storage condition

(Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible )

color

yellow to orange

solubility

DMF: 2-4 mg/mL
DMSO: 30-40 mg/mL
H2O: insoluble
water: insoluble

antibiotic activity spectrum

fungi
yeast

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

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Description

General description

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. and has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes.

Application

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, [1] and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers [2][3]. It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-

for amphotericin perforated patch technique[4]
as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay[5][6][7]
as a component of Arcobacter selective isolation broth[8]

Biochem/physiol Actions

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out.

Antimicrobial spectrum: Includes fungi and yeast

Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. The product is most effective against fungi and yeast.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.