کانامایسین سولفات سیگما Kanamycin sulfate 60615

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60615

Kanamycin sulfate

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mixture of Kanamycin A (main component) and Kanamycin B and C

Linear Formula:C18H36-37N4-5O10-11 · H2SO4CAS Number:70560-51-9Beilstein:3874279MDL number:MFCD00070253PubChem Substance ID:57651778NACRES:NA.85

DESCRIPTION

General description

Chemical structure: aminoglycoside

Application

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.†† Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.

Biochem/physiol Actions

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Packaging

5g, 25 g

Caution

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Preparation Note

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Product Name : Kanamycin sulfate mixture of Kanamycin A (main component) and Kanamycin B and C Product Number : 60615-5G Batch Number : 0000240307 Source Batch : N1120.22 CAS Number : 70560-51-9 Expiry Date : Mar 2025 Quality Release Date : 30 May 2023 Test Specification Result Appearance (Color) White to Off White White Appearance (Form) Powder or Crystals Powder Loss on Drying ≤ 1.5 % 0.7 % Sulfated Ash ≤ 0.5 % 0.1 % Specific Rotation 112 - 123 ° 119 ° Identification Conforms Conforms Potency ≥ 750 761 UN/mg (calculated with reference to the dried substance)