هموگلوبین خون گاو Hemoglobin from bovine blood H2500 SIGMA

Name: هموگلوبین خون گاو Hemoglobin from bovine blood H2500 SIGMA
SKU: IN1714971680
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هموگلوبین خون گاو Hemoglobin from bovine blood H2500 SIGMA

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Hemoglobin from bovine blood

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lyophilized powder

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Change View1 G€60.605 G€234.0010 G€431.0025 G€800.00Synonym(s):Bovine hemoglobin, Hb, MethemoglobinCAS Number:9008-02-0MDL number:MFCD00131282eCl@ss:42030116NACRES:NA.61

PROPERTIES

biological source

bovine blood

Quality Level

300

form

lyophilized powder

mol wt

Mr ~64500

technique(s)

MALDI-TOF: suitable

UniProt accession no.

P01966
P02070
P02081
P06642
P06643

storage temp.

2-8°C

Gene Information

cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)

DESCRIPTION

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%.[1] Hemoglobin is a globular protein with α and β chains with each 141 and 146 amino acids, respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme.[1]

Application

Hemoglobin from bovine blood has been used in:

standard curve generation for the quantification intraparenchymal hemorrhage[2] and parenchymal hemorrhage[3] in spinal cord homogenate using Drabkin′s assay, Quadrupole-Ion Mobility-Time-of-Flight mass spectrometery [4]
the generation of molecularly imprinted polymers (MIPs) to mimic high molecular-weight polyethylene glycol (PEG) in crystallization studies[5]

The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.

Biochem/physiol Actions

Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.[1] Bovine hemoglobin is used in the generation of hemoglobin-vesicles (HbV) for oxygen transport.[6] It is thermally stable and displays high affinity to oxygen when compared to human hemoglobin.[6] Bovine hemoglobin interacts with synthetic and azo dyes.[7] Polymerized forms of bovine haemoglobin is recommended for treating autoimmune hemolytic anemia.[8]Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.