کوردلان (بتا 1و3 گلوکان) Curdlan from Alcaligenes faecalis, ≥98% (TLC), solid C7821-5G SIGMA سیگما

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برگه انالیز کالا ( کلیک کنید )

C7821

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Curdlan

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from Alcaligenes faecalis, ≥98% (TLC), solid

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5 G

€353.00

Synonym(s):

β-1,3-Glucan hydrate

CAS Number:

54724-00-4

MDL number:

MFCD00212920

UNSPSC Code:

12352200

NACRES:

NA.77

Properties

product name

Curdlan from Alcaligenes faecalis,

form

solid

Quality Level

200

storage temp.

2-8°C

Description

General description

Curdlan is an insoluble natural polymer with linear structure[1] mainly produced by Alcaligenes faecalis.[2] It is a dietary fiber with gelatin properties.[1][2]

Application

Curdlan from Alcaligenes faecalis has been used:

• for the stimulation of carp macrophages for regulation of differentially expressed genes[3]

• to stimulate human intestinal epithelial cells for cytokine secretion[4]

• to study its effect on transcriptional responses of inflammation/respiratory burst-associated genes in mouse alveolar macrophages by customized reverse transcription (RT)-PCR based arrays[5]

• as a substrate in β-1,3–1,4-Glucanase activity assay[6]

Biochem/physiol Actions

Curdlan is used as a food additive in the food industry.[1] It improves the elasticity and reduces the embrittling tendency of hydroxyapatite/chitosan scaffold, which aids in bone regeneration.[7]

Curdlan is a (1,3)-β-glucan. It is a pathogen-associated molecular-pattern (PAMP) recognized by the receptor dectin-1. Activation of dectin-1, together with TLR2/TLR6, promotes signaling resulting in the production of pro-inflammatory cytokines, thus inducing inflammation.

Preparation Note

For gelation at 70 °C, the concentration of the sodium hydroxide should be 0.01 M.