کلشیسین Colchicine ≥95% (HPLC), powder, antimitotic agent C9754-1G SIGMA
کلشیسین Colchicine ≥95% (HPLC), powder, antimitotic agent C9754-1G SIGMA
لینک کالا در سایت سیگما ( کلیک کنید )
برگه انالیز کالا ( کلیک کنید )
C9754
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Colchicine
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≥95% (HPLC), powder, antimitotic agent
Synonym(s):
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
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100 MG
€24.60
500 MG
€82.40
1 G
€136.00
5 G
€547.00
About This Item
Empirical Formula (Hill Notation):
C22H25NO6
CAS Number:
Molecular Weight:
399.44
Beilstein:
2228813
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Properties
product name
Colchicine, ≥95% (HPLC), powder
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to yellow
mp
150-160 °C (dec.) (lit.)
solubility
ethanol: 50 mg/mL
SMILES string
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChI key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Gene Information
human ... ABCB1(5243) , CYP3A4(1576) , TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)
mouse ... Abcb1a(18671) , Abcb1b(18669)
Description
General description
Colchicine is a secondary metabolite,[1] which has anti-inflammatory properties.[2] It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines.[2] It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.[1]
Application
Colchicine has been used:
in the in vitro sister-chromatid exchange (SCE) assay[3]
to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities[4]
in microtubule disruption[5]
to analyse its effects on Ca2+ transients from taxol-treated cells[6]
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage and Stability
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.