رفرنس استاندارد اوستول

Osthole

Y0001207

لینک کالا در سایت سیگما ( کلیک کنید )

لینک کالا در سایت EDQM ( کلیک کنید )

برگه انالیز کالا ( کلیک کنید )

European Pharmacopoeia (EP) Reference Standard

Synonym(s)

7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol

About This Item

Empirical Formula (Hill Notation)

C15H16O3

CAS Number

484-12-8

Molecular Weight

244.29

MDL number

MFCD00076049

UNSPSC Code

41116107

PubChem Substance ID

329831307

NACRES

NA.24

Properties

grade

pharmaceutical primary standard

API family

osthole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp

2-8°C

SMILES string

COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C

InChI

1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

InChI key

MBRLOUHOWLUMFF-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia

Application

Osthole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia

Biochem/physiol Actions

Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy