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رفرنس استاندارد کوله کلسیفرول (ویتامین دی 3) Cholecalciferol (Vitamin D3) PHR1237 SIGMA

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رفرنس استاندارد کوله کلسیفرول (ویتامین دی 3) Cholecalciferol (Vitamin D3) PHR1237 SIGMA

Name: رفرنس استاندارد کوله کلسیفرول (ویتامین دی 3) Cholecalciferol (Vitamin D3) PHR1237 SIGMA
SKU: IN1714972250
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رفرنس استاندارد کوله کلسیفرول (ویتامین دی 3) Cholecalciferol (Vitamin D3) PHR1237 SIGMA

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PHR1237

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Cholecalciferol (Vitamin D3)

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Pharmaceutical Secondary Standard; Certified Reference Material

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Change View500 MG€135.00Synonym(s):Cholecalciferol, (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, CalciolEmpirical Formula (Hill Notation):C27H44OCAS Number:67-97-0Molecular Weight:384.64Beilstein:2339331EC Number:200-673-2MDL number:MFCD00078131PubChem Substance ID:329823242NACRES:NA.24

PROPERTIES

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 787
traceable to Ph. Eur. C2100000
traceable to USP 1131009

API family

cholecalciferol

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

83-86 °C (lit.)

application(s)

food and beverages

format

neat

DESCRIPTION

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.[1]

Application

Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds,[2] serum samples[3] and pharmaceutical formulations[4][2][3] by various chromatography techniques.These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.