استاندارد آستاگزانتین Astaxanthin SML0982-50MG SIGMA

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SML0982

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Astaxanthin

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≥97% (HPLC), from Blakeslea trispora

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50 MG

€161.00

Synonym(s):

3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin

Empirical Formula (Hill Notation):

C40H52O4

CAS Number:

7542-45-2

Molecular Weight:

596.84

UNSPSC Code:

12352200

NACRES:

NA.77

Properties

biological source

Blakeslea trispora

Quality Level

100

Assay

≥97% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

, pink to very dark purple

solubility

DMSO: 1 mg/mL (warmed)

storage temp.

−20°C

InChI

1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1

InChI key

MQZIGYBFDRPAKN-UWFIBFSHSA-N

Description

General description

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.[1]

Application

Astaxanthin has been used:

• as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth[2]

• to study its effects on the treatment of diabetic retinopathy.[2][3]

• to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.[1]

Biochem/physiol Actions

In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease.[1] Due to its bright red colour, AST has been used as a food colorant in animal feeds.[3]

Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

Other Notes

Light and air sensitive