۶هیدروکسی دوپامین هیدروکلراید سیگما

کد کالا: H4381

لینک کالا در سایت سیکما ( کلیک کنید )

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H4381

6-Hydroxydopamine hydrochloride

≥97% (titration), powder

Synonym(s):
2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA

Linear Formula:
(HO)3C6H2CH2CH2NH2 · HCl

CAS Number:
28094-15-7
Molecular Weight:
205.64
Beilstein:
4274007
EC Number:
248-837-2
MDL number:
MFCD00012895
PubChem Substance ID:
24895641
NACRES:
NA.77

General description

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.[1][2] 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.[2]

Application

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats[1]
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line[3]
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus[2]

Packaging

100, 500 mg in glass insert1 g in glass bottle

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

Caution

Hygroscopic

Reconstitution

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.