سیلیمارین S0292-10G Silymarin SIGMA

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S0292

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Silymarin

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flavonolignans

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10 G

$60.30

50 G

$179.00

Synonym(s):

flavolignans

CAS Number:

65666-07-1

MDL number:

MFCD01776359

NACRES:

NA.81

Properties

biological source

plant (Silybum marianum)

Quality Level

200

form

powder

technique(s)

toxicology assay: suitable

application(s)

microbiology

storage temp.

−20°C

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

InChI key

SEBFKMXJBCUCAI-UHFFFAOYSA-N

Description

General description

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.[1]

Application

Silymarin has been used to study:

• its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity[1]

• its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model[2]

• its effect on liver toxication induced by Fumonisin B1 in mice [3]

Biochem/physiol Actions

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.[1]

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin. [4]

Other Notes

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.