بربرین کلراید Berberine chloride form B3251-5G SIGMA

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B3251

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Berberine chloride form

Synonym(s):

Benzodioxide, Berberine HCl, Natural Yellow 18

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5 G

€78.50

10 G

€148.00

25 G

€311.00

About This Item

Empirical Formula (Hill Notation):

C20H18ClNO4

CAS Number:

633-65-8

Molecular Weight:

371.81

Colour Index Number:

75160

Beilstein:

3836585

EC Number:

211-195-9

MDL number:

MFCD00011939

UNSPSC Code:

12171500

PubChem Substance ID:

24891691

NACRES:

NA.32

form

powder

Quality Level

200

solubility

methanol: soluble

SMILES string

COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChI key

VKJGBAJNNALVAV-UHFFFAOYSA-M

Description

General description

Berberine Chloride form or Natural Yellow 18, is also known as 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium is a benzyl tetra isoquinoline plant alkaloid. Berberine contains a quaternary base and is commercially available in berberine chloride form.

Application

Berberine Chloride is a fluorescent stain used to stain heparin in mast cells. Berberine upregulates the expression of Pgp in hepatoma cells.

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.